Altered Cholesterol Biosynthesis Affects Drug Metabolism
نویسندگان
چکیده
منابع مشابه
Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function.
Niemann-Pick type C1 (NPC1) disease is a fatal hereditary disorder characterized by a defect in cholesterol trafficking and progressive neurodegeneration. Although the NPC1 gene has been identified, the molecular mechanism responsible for neuronal dysfunction in brains of patients with NPC1 disease remains unknown. This study demonstrates that the amount of cholesterol within mitochondria membr...
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ژورنال
عنوان ژورنال: ACS Omega
سال: 2021
ISSN: 2470-1343,2470-1343
DOI: 10.1021/acsomega.0c05817